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A recent systematic review and meta-analysis of 25 observational studies found proton-pump inhibitor use was associated with a small increased risk of vitamin B 12 deficiency

Without a preservative, reconstituted solutions are vulnerable to microbial growth

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doi: 10.21542/gcsp.2018.13 375

This lack of significant improvement may be attributed to the activation of VEGF-independent angiogenic pathways, the recruitment of proangiogenic stromal cells, the induction of vasculogenesis or even the dose of the antiangiogenic agent used, which may reduce the size of blood vessel pores, further obstructing the delivery of this antibody [30, 39, 40]